Structure of PDB 6h3c Chain G

Receptor sequence
>6h3cG (length=258) Species: 9606 (Homo sapiens) [Search protein sequence]
AVQAVHLESDAFLVCLNHALSTEKEEVMGLCIGELNDDTVRIVHIHSVII
LRRSDKRKDRVEISPEQLSAASTEAERLAELTGRPMRVVGWYHSHPHITV
WPSHVDVRTQAMYQMMDQGFVGLIFSCFIEDKNTKTGRVLYTCFQSIQAQ
YERIEIPIHIVPHVTIGKVCLESAVELPKILCQEEQDAYRRIHSLTHLDS
VTKIHNGSVFTKNLCSQMSAVSGPLLQWLEDRLEQNQQHLQELQQEKEEL
MQELSSLE
3D structure
PDB6h3c Structural Basis of BRCC36 Function in DNA Repair and Immune Regulation.
ChainG
Resolution3.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.19.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN G H122 H124 D135 H93 H95 D106
Gene Ontology
Molecular Function
GO:0004843 cysteine-type deubiquitinase activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008237 metallopeptidase activity
GO:0030234 enzyme regulator activity
GO:0031593 polyubiquitin modification-dependent protein binding
GO:0046872 metal ion binding
GO:0061578 K63-linked deubiquitinase activity
GO:0140492 metal-dependent deubiquitinase activity
Biological Process
GO:0006281 DNA repair
GO:0006282 regulation of DNA repair
GO:0006302 double-strand break repair
GO:0006325 chromatin organization
GO:0006508 proteolysis
GO:0007095 mitotic G2 DNA damage checkpoint signaling
GO:0010165 response to X-ray
GO:0010212 response to ionizing radiation
GO:0016579 protein deubiquitination
GO:0044818 mitotic G2/M transition checkpoint
GO:0045739 positive regulation of DNA repair
GO:0051301 cell division
GO:0070536 protein K63-linked deubiquitination
GO:0071479 cellular response to ionizing radiation
GO:0140861 DNA repair-dependent chromatin remodeling
GO:1900227 positive regulation of NLRP3 inflammasome complex assembly
GO:2000001 regulation of DNA damage checkpoint
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0000152 nuclear ubiquitin ligase complex
GO:0000922 spindle pole
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0070531 BRCA1-A complex
GO:0070552 BRISC complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6h3c, PDBe:6h3c, PDBj:6h3c
PDBsum6h3c
PubMed31253574
UniProtP46736|BRCC3_HUMAN Lys-63-specific deubiquitinase BRCC36 (Gene Name=BRCC3)

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