Structure of PDB 6gqv Chain G

Receptor sequence

>6gqvG (length=233) Species: 4932 (Saccharomyces cerevisiae)

NPLTHSTPKNFGIGQAVQPKRNLSRYVKWPEYVRVQRQKKILSIRLKVPP
TIAQFQYTLDRNTAAETFKLFNKYRPETAAEKKERLTKEAAAVAEGKSKQ
DASPKPYAVKYGLNHVVALIENKKAKLVLIANDVDPIELVVFLPALCKKM
GVPYAIVKGKARLGTLVNQKTSAVAALTEVRAEDEAALAKLVSTIDANFA
DKYDEVKKHWGGGILGNKAQAKMDKRAKNSDSA

3D structure

• PDB: 6gqv Structural Insights into the Role of Diphthamide on Elongation Factor 2 in mRNA Reading-Frame Maintenance.
• Chain: G
• Resolution: 4.0 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	G	H28 T30 P31 K32 F34 G35 I36 Q41 K43 L46 R48 Y49 K51 P53 Y55 R60 L65 R68 K70 K105 R108 D124 S126 P127 P129 K133 Y134 G135 L136 N137 H138 A141 L142 N145 K147 V157 P159 K183 Q192 K193 S195 N240 K241 A242 K248	H5 T7 P8 K9 F11 G12 I13 Q18 K20 L23 R25 Y26 K28 P30 Y32 R37 L42 R45 K47 K82 R85 D101 S103 P104 P106 K110 Y111 G112 L113 N114 H115 A118 L119 N122 K124 V134 P136 K160 Q169 K170 S172 N217 K218 A219 K225
BS02	rna	G	Y55 Q59 R60 K63 R84 K181 R185	Y32 Q36 R37 K40 R61 K158 R162

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0000470 maturation of LSU-rRNA
• GO:0002181 cytoplasmic translation
• GO:0006364 rRNA processing
• GO:0042254 ribosome biogenesis

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6gqv, PDBe:6gqv, PDBj:6gqv
• PDBsum: 6gqv
• PubMed: 29886014
• UniProt: P17076|RL8A_YEAST Large ribosomal subunit protein eL8A (Gene Name=RPL8A)