Structure of PDB 6fog Chain G

Receptor sequence
>6fogG (length=217) Species: 9606 (Homo sapiens) [Search protein sequence]
ASRPLSRFWEWGKNIVCVGRNYADHVREMRSAVLSEPVLFLKPSTAYAPE
GSPILMPAYTRNLHHELELGVVMGKRCRAVPEAAAMDYVGGYALCLDMTA
RDVQDECKKKGLPWTLAKSFTASCPVSAFVPKEKIPDPHKLKLWLKVNGE
LRQEGETSSMIFSIPYIISYVSKIITLEEGDIILTGTPKGVGPVKENDEI
EAGIHGLVSMTFKVEKP
3D structure
PDB6fog Structural basis for the bi-functionality of human oxaloacetate decarboxylase FAHD1.
ChainG
Resolution1.94 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.7.1.5: acylpyruvate hydrolase.
4.1.1.112: oxaloacetate decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG G E71 E73 D102 E66 E68 D97
BS02 OXL G G24 R25 F45 E71 T192 G19 R20 F40 E66 T187
BS03 MG G K18 N19 K13 N14
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0008948 oxaloacetate decarboxylase activity
GO:0016787 hydrolase activity
GO:0016829 lyase activity
GO:0016853 isomerase activity
GO:0018773 acetylpyruvate hydrolase activity
GO:0034545 fumarylpyruvate hydrolase activity
GO:0046872 metal ion binding
GO:0047621 acylpyruvate hydrolase activity
GO:0050163 oxaloacetate tautomerase activity
Biological Process
GO:0006090 pyruvate metabolic process
GO:0006107 oxaloacetate metabolic process
Cellular Component
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005829 cytosol

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Molecular Function
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Cellular Component
External links
PDB RCSB:6fog, PDBe:6fog, PDBj:6fog
PDBsum6fog
PubMed30348641
UniProtQ6P587|FAHD1_HUMAN Oxaloacetate tautomerase FAHD1, mitochondrial (Gene Name=FAHD1)

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