Structure of PDB 6eot Chain G

Receptor sequence
>6eotG (length=836) Species: 9606 (Homo sapiens) [Search protein sequence]
LEPFYVERYSWSQLKKLLADTRKYHKAPHDFMFVKRNDPDGPHSDRIYYL
AMRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATYSREEELLRERKRI
GTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSC
PNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEE
DARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEV
EIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVID
KELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPEL
FIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHE
EEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEE
IAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPG
EVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTC
KTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKK
YPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRG
LKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLS
LMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSV
AMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYP
QERHSIRVPESGEHYELHLLHYLQENLGSRIAALKV
3D structure
PDB6eot Structures and mechanism of dipeptidyl peptidases 8 and 9, important players in cellular homeostasis and cancer.
ChainG
Resolution3.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y669 S755 Y756 D833 H865
Catalytic site (residue number reindexed from 1) Y608 S694 Y695 D772 H804
Enzyme Commision number 3.4.14.5: dipeptidyl-peptidase IV.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide G R160 E275 E276 Y669 Q673 K685 W754 S755 Y756 V781 W784 Y787 Y791 H865 S866 I867 G873 E877 R99 E214 E215 Y608 Q612 K624 W693 S694 Y695 V720 W723 Y726 Y730 H804 S805 I806 G812 E816
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0005515 protein binding
GO:0008236 serine-type peptidase activity
GO:0008239 dipeptidyl-peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0006915 apoptotic process
GO:0006955 immune response
GO:0043069 negative regulation of programmed cell death
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6eot, PDBe:6eot, PDBj:6eot
PDBsum6eot
PubMed29382749
UniProtQ6V1X1|DPP8_HUMAN Dipeptidyl peptidase 8 (Gene Name=DPP8)

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