Structure of PDB 6ea8 Chain G

Receptor sequence
>6ea8G (length=194) Species: 10254 (Vaccinia virus WR) [Search protein sequence]
MAMFYAHALGGYDENLHAFPGISSTVANDVRKYSVVSVYNNKYDIVKDKY
MWCYSQVNKRYIGALLPMFECNEYLQIGDPIHDQEGNQISIITYRHKNYY
ALSGIGYESLDLCLEGVGIHHHVLETGNAVYGKVQHDYSTIKEKAKEMNA
LSPGPIIDYHVWIGDCICQVTAVDVHGKEIMRMRFKKGAVLPIP
3D structure
PDB6ea8 Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS-STING signalling.
ChainG
Resolution2.6 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 J2B G A129 Y138 K142 A145 N149 I167 R184 K186 A129 Y138 K142 A145 N149 I167 R184 K186
Gene Ontology
Molecular Function
GO:0004518 nuclease activity
GO:0061507 2',3'-cyclic GMP-AMP binding
Biological Process
GO:0052170 symbiont-mediated suppression of host innate immune response
Cellular Component
GO:0030430 host cell cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6ea8, PDBe:6ea8, PDBj:6ea8
PDBsum6ea8
PubMed30728498
UniProtQ01225|POXIN_VACCW Poxin (Gene Name=OPG188)

[Back to BioLiP]