Structure of PDB 6du7 Chain G

Receptor sequence
>6du7G (length=448) Species: 1313 (Streptococcus pneumoniae) [Search protein sequence]
MREYDIIAIGGGSGGIATMNRAGEHGAQAAVIEEKKLGGTCVNVGCVPKK
IMWYGAQIAETFHQFGEDYGFKTTDLNFDFATLRRNRESYIDRARSSYDG
SFKRNGVDLIEGHAEFVDSHTVSVNGELIRAKHIVIATGAHPSIPNIPGA
ELGGSSDDVFAWEELPESVAILGAGYIAVELAGVLHTFGVKTDLFVRRDR
PLRGFDSYIVEGLVKEMERTNLPLHTHKVPVKLEKTTDGITIHFEDGTSH
TASQVIWATGRRPNVKGLQLEKAGVTLNERGFIQVDEYQNTVVEGIYALG
DVTGEKELTPVAIKAGRTLSERLFNGKTTAKMDYSTIPTVVFSHPAIGTV
GLTEEQAIKEYGQDQIKVYKSSFASMYSACTRNRQESRFKLITAGSEEKV
VGLHGIGYGVDEMIQGFAVAIKMGATKADFDATVAIHPTSSEEFVTMR
3D structure
PDB6du7 The structure and activity of the glutathione reductase from Streptococcus pneumoniae.
ChainG
Resolution2.56 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C41 C46 K49 Y176 E180 H437 E442
Catalytic site (residue number reindexed from 1) C41 C46 K49 Y176 E180 H437 E442
Enzyme Commision number 1.8.1.7: glutathione-disulfide reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD G G12 S13 E33 E34 G39 T40 C41 G45 C46 K49 H113 A114 T138 Y176 I177 R261 D301 L308 T309 G12 S13 E33 E34 G39 T40 C41 G45 C46 K49 H113 A114 T138 Y176 I177 R261 D301 L308 T309
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004362 glutathione-disulfide reductase (NADPH) activity
GO:0016491 oxidoreductase activity
GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
GO:0050660 flavin adenine dinucleotide binding
GO:0050661 NADP binding
Biological Process
GO:0006749 glutathione metabolic process
GO:0034599 cellular response to oxidative stress
GO:0045454 cell redox homeostasis
GO:0098869 cellular oxidant detoxification
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6du7, PDBe:6du7, PDBj:6du7
PDBsum6du7
PubMed30605126
UniProtA0A0U0ARX4

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