Structure of PDB 6dft Chain G

Receptor sequence
>6dftG (length=367) Species: 5691 (Trypanosoma brucei) [Search protein sequence]
KQVVVGPNQEDLHSAEAVLNRYSTVGFQASNLARAFSICEMMLTPQSPSP
SQPTLFVGVTANLFGTGCREAIRFLCTECVPLPNGVEPATPLPSPCDSRA
LIHVLVVSGGAMEHDIRRACESYKLSRDCHFGNVRYNSSGVASRNLFSCV
MRCLVKRLAEAQRKEKANREDVCSWAITPSTLWYMAGLWMADIFTEALQE
TGEVTDEKVASEEGLKRAKSTVLYWAARNGVPIFSPSLTDGDIMEFILTA
GDTGVPLLQLDLVADIHRLNRLAMRSRRTGMMILGGGVVKHHVCNANLMR
NGADYAVFLNNAQEFDGSDAGARPGEAVSWGKLRLDSTAVKVYSEVTIVF
PLIVVHVFVAWVRMMRS
3D structure
PDB6dft Trypanosomatid Deoxyhypusine Synthase Activity Is Dependent on Shared Active-Site Complementation between Pseudoenzyme Paralogs.
ChainG
Resolution3.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.46: deoxyhypusine synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD G T98 S161 G162 S323 D326 D328 G372 N397 A398 E431 V432 T60 S108 G109 S237 D240 D242 G286 N311 A312 E345 V346
BS02 NAD G G373 V374 H377 D402 S404 D405 A406 G287 V288 H291 D316 S318 D319 A320
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0034038 deoxyhypusine synthase activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0008216 spermidine metabolic process
GO:0008612 peptidyl-lysine modification to peptidyl-hypusine
GO:0051290 protein heterotetramerization
GO:2000765 regulation of cytoplasmic translation
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane
GO:1902494 catalytic complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6dft, PDBe:6dft, PDBj:6dft
PDBsum6dft
PubMed30197036
UniProtQ38BX0|DHYSC_TRYB2 Deoxyhypusine synthase (Gene Name=DHSc)

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