Structure of PDB 6bwy Chain G

Receptor sequence
>6bwyG (length=346) Species: 9606,284812 [Search protein sequence]
QLNELLNAGEYKIGELTFQSIRSSQELQKKNTIVNLFGIVKDFTPSRQSL
HGTKDWVTTVYLWDPTCDTSSIGLQIHLFSKQGNDLPVIKQVGQPLLLHQ
ITLRSYRDRTQGLSKDQFRYALWPDFSSNSKDTLCPQPMPRLMKTGDKEE
QFALLLNKIWDEQTNHSMDPPTFTFNFNNEPWVRGRHETYLCYEVERMHN
DTWVKLNQRRGFLANQAPEGRHAELCFLDVIPFWKLDLDQDYRVTCFTSW
SPCFSCAQEMAKFISKNKHVSLCIKTARIYDDQGRAQEGLRTLAEAGAKI
SIMTYSEFKHCWDTFVDHQGAPFQPWDGLDEHSQDLSGRLRAILQN
3D structure
PDB6bwy Insights into DNA substrate selection by APOBEC3G from structural, biochemical, and functional studies.
ChainG
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.4.-
3.5.4.38: single-stranded DNA cytosine deaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna G S78 L79 H80 G81 T82 D84 H106 F108 T131 R133 Y135 Q140 L142 S143 K144 D145 S49 L50 H51 G52 T53 D55 H77 F79 T102 R104 Y106 Q111 L113 S114 K115 D116 PDBbind-CN: Kd=26uM
BS02 ZN G H257 C288 C291 H222 C253 C256
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
Biological Process
GO:0000723 telomere maintenance
Cellular Component
GO:0000781 chromosome, telomeric region

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6bwy, PDBe:6bwy, PDBj:6bwy
PDBsum6bwy
PubMed29596531
UniProtO13988|POT1_SCHPO Protection of telomeres protein 1 (Gene Name=pot1);
Q9HC16|ABC3G_HUMAN DNA dC->dU-editing enzyme APOBEC-3G (Gene Name=APOBEC3G)

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