Structure of PDB 5zr3 Chain G

Receptor sequence
>5zr3G (length=212) Species: 9606 (Homo sapiens) [Search protein sequence]
MEEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRY
ESLTDPSKLDSGKELHINLIPNKQDRTLTIVDTGIGMTKADLINNLGTIA
KSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYA
WESSAGGSFTVRTDTGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKHS
QFIGYPITLFVE
3D structure
PDB5zr3 Discovery of 3-Ethyl-4-(3-isopropyl-4-(4-(1-methyl-1 H-pyrazol-4-yl)-1 H-imidazol-1-yl)-1 H-pyrazolo[3,4- b]pyridin-1-yl)benzamide (TAS-116) as a Potent, Selective, and Orally Available HSP90 Inhibitor.
ChainG
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.10: non-chaperonin molecular chaperone ATPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 9J0 G F22 M98 L103 I104 G108 F138 Y139 W162 F170 F11 M87 L92 I93 G97 F127 Y128 W151 F159 MOAD: ic50=98nM
BindingDB: IC50=150nM
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0051082 unfolded protein binding
GO:0140662 ATP-dependent protein folding chaperone
Biological Process
GO:0006457 protein folding

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Molecular Function
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Biological Process
External links
PDB RCSB:5zr3, PDBe:5zr3, PDBj:5zr3
PDBsum5zr3
PubMed30525599
UniProtP07900|HS90A_HUMAN Heat shock protein HSP 90-alpha (Gene Name=HSP90AA1)

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