Structure of PDB 5zoo Chain G

Receptor sequence
>5zooG (length=387) Species: 9606 (Homo sapiens) [Search protein sequence]
FTTGLVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECI
RGRKATLEELQTVHSEAHTLLYGTNPLSVFVRLPCGGVGVDSDTIWNEVH
SAGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFN
SVAVAAKLLQQRLSVSKILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYD
DGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAFRTVVM
PIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQLMGLAGG
RIVLALEGGYDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRS
MEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEA
3D structure
PDB5zoo Structural basis of the specific interaction of SMRT corepressor with histone deacetylase 4.
ChainG
Resolution1.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.1.98: histone deacetylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide G D759 M810 F812 G868 F870 F871 P872 P942 D93 M144 F146 G202 F204 F205 P206 P276
BS02 ZN G D840 H842 D934 D174 H176 D268
BS03 ZN G C667 C669 H675 C751 C16 C18 H24 C85
External links
PDB RCSB:5zoo, PDBe:5zoo, PDBj:5zoo
PDBsum5zoo
PubMed30321390
UniProtP56524|HDAC4_HUMAN Histone deacetylase 4 (Gene Name=HDAC4)

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