Structure of PDB 5whe Chain G

Receptor sequence
>5wheG (length=154) Species: 9606 (Homo sapiens) [Search protein sequence]
TEYKLVVVGAVGVGKSALTIQLIQNPSYRKQVVIDGETCLLDILDTAGQE
EYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMV
LVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVRE
IRKH
3D structure
PDB5whe Exceptionally high-affinity Ras binders that remodel its effector domain.
ChainG
Resolution1.91 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GNP G G13 G15 K16 S17 A18 N116 K117 D119 L120 S145 A146 K147 G12 G14 K15 S16 A17 N104 K105 D107 L108 S133 A134 K135
BS02 CA G E63 Y64 E51 Y52
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5whe, PDBe:5whe, PDBj:5whe
PDBsum5whe
PubMed29282294
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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