Structure of PDB 5whb Chain G

Receptor sequence
>5whbG (length=158) Species: 9606 (Homo sapiens) [Search protein sequence]
TEYKLVVVGAVGVGKSALTIQLIQNHFVEDSYRKQVVIDGETCLLDILDT
AGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSED
VPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYT
LVREIRKH
3D structure
PDB5whb Exceptionally high-affinity Ras binders that remodel its effector domain.
ChainG
Resolution2.18 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide G E3 K5 D38 Y40 R41 I55 L56 D57 T58 E63 R68 Y71 E2 K4 D30 Y32 R33 I47 L48 D49 T50 E55 R60 Y63
BS02 GDP G V12 G13 G15 K16 S17 A18 F28 N116 K117 D119 S145 A146 V11 G12 G14 K15 S16 A17 F27 N108 K109 D111 S137 A138
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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External links
PDB RCSB:5whb, PDBe:5whb, PDBj:5whb
PDBsum5whb
PubMed29282294
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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