Structure of PDB 5un1 Chain G

Receptor sequence
>5un1G (length=424) Species: 8355 (Xenopus laevis) [Search protein sequence]
MSTRLKIVTIHQEPFVYVRPTTSDGTCREEYTINGDPIKKVICNGPDETI
PGRPTVPQCCYGFCVDLLIKLAREMDFTYEVHLVADGKFGTQERVNNSNA
AAWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKE
IPRSTLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSTLSSAMWFSWR
VLLNSGLGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLRRPEE
RITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTMYRHMEKHNYE
SAAEAIQAVRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGM
RKDSPWKQEVSLNILKSHENGFMEELDKTWVRYQECDSRSNAPATLTFEN
MAGVFMLVAGGIVAGIFLIFIEIA
3D structure
PDB5un1 Mechanism of NMDA receptor channel block by MK-801 and memantine.
ChainG
Resolution3.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLY G F482 P514 L515 T516 R521 S678 D722 F89 P121 L122 T123 R128 S276 D320
BS02 GLU G I426 Y454 I33 Y61
BS03 BMK G V634 A635 V232 A233 PDBbind-CN: -logKd/Ki=5.80,Kd=1.6uM
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0015276 ligand-gated monoatomic ion channel activity
GO:0038023 signaling receptor activity
Biological Process
GO:0006811 monoatomic ion transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:5un1, PDBe:5un1, PDBj:5un1
PDBsum5un1
PubMed29670280
UniProtA0A1L8F5J9|NMDZ1_XENLA Glutamate receptor ionotropic, NMDA 1 (Gene Name=grin1)

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