Structure of PDB 5tt3 Chain G

Receptor sequence
>5tt3G (length=218) Species: 85962 (Helicobacter pylori 26695) [Search protein sequence]
TKWDYKNKENGPHRWDKLHKDFEVCKSGKSQSPINIEHYYHTQDLQFKYA
ASKPKAVFFTHHTLKASFEPTNHINYRGHDYVLDNVHFHAPMEFLINNKT
RPLSAHFVHKDAKGRLLVLAIGFEEGKENPNLDPILEGIQKKQLDAFLPK
SINYYHFNGSLTAPPCTEGVAWFVIEEPLEVSAKQLAEIKKRMKNSPNQR
PVQPDYNTVIIKSSAETR
3D structure
PDB5tt3 Structure-Activity Relationship for Sulfonamide Inhibition of Helicobacter pylori alpha-Carbonic Anhydrase.
ChainG
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H85 H110 H112 E116 H129 T191
Catalytic site (residue number reindexed from 1) H62 H87 H89 E93 H106 T162
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN G H110 H112 H129 H87 H89 H106
BS02 EZL G H110 H112 H129 L190 T191 P193 W201 H87 H89 H106 L161 T162 P164 W172 MOAD: Ki=193nM
Gene Ontology
Molecular Function
GO:0004089 carbonate dehydratase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:5tt3, PDBe:5tt3, PDBj:5tt3
PDBsum5tt3
PubMed28002963
UniProtA0A0M3KL20

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