Structure of PDB 5sdt Chain G

Receptor sequence

>5sdtG (length=434) Species: 9606 (Homo sapiens)

RRADVAQLTQELGTAFFQQQQLPAAMADTFLEHLCLLDIDSEPVAARSTS
IIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVE
SFAGSPLSYRPVAIALDTKGPPGLSEQDVRDLRFGVEHGVDIVFASFVRK
ASDVAAVRAALGPEGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGDL
GIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSD
VANAVLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEE
LRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPR
AAVIAVTRSAQAARQVHLCRGVFPLLYREPPEAIWADDVDRRVQFGIESG
KLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLSIS

3D structure

• PDB: 5sdt Anthraquinone derivatives as ADP-competitive inhibitors of liver pyruvate kinase.
• Chain: G
• Resolution: 1.944 Å

Enzymatic activity

• Enzyme Commision number: 2.7.1.40: pyruvate kinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FBP	G	L443 T444 T445 T446 S449 W494 R501 G526 R528 P529 G530 S531 G532 Y533 T534	L334 T335 T336 T337 S340 W385 R392 G417 R419 P420 G421 S422 G423 Y424 T425
BS02	OXL	G	K282 E284 A305 G307 D308 T340	K173 E175 A196 G198 D199 T231
BS03	I9Q	G	T62 P65 N87 H90 Y95 S374 G375 A378 K379	T54 P57 N79 H82 Y87 S265 G266 A269 K270
BS04	MG	G	E284 D308	E175 D199

Gene Ontology

Molecular Function

• GO:0000287 magnesium ion binding
• GO:0003824 catalytic activity
• GO:0004743 pyruvate kinase activity
• GO:0030955 potassium ion binding

Biological Process

• GO:0006096 glycolytic process

External links

• PDB: RCSB:5sdt, PDBe:5sdt, PDBj:5sdt
• PDBsum: 5sdt
• PubMed: 35290845
• UniProt: P30613|KPYR_HUMAN Pyruvate kinase PKLR (Gene Name=PKLR)