Structure of PDB 5sca Chain G

Receptor sequence
>5scaG (length=423) Species: 9606 (Homo sapiens) [Search protein sequence]
LGTAFFQQQQLPAAMADTFLEHLCLLDIDSEPVAARSTSIIATIGPASRS
VERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSPLSYRP
VAIALDTKGPPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAAL
GPEGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFL
AQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADC
IMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDP
TEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQ
AARQVHLCRGVFPLLYREPPEAIWADDVDRRVQFGIESGKLRGFLRVGDL
VIVVTGWRPGSGYTNIMRVLSIS
3D structure
PDB5sca Anthraquinone derivatives as ADP-competitive inhibitors of liver pyruvate kinase.
ChainG
Resolution1.918 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.40: pyruvate kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FBP G L443 T444 T445 T446 S449 W494 R501 G526 R528 P529 G530 S531 Y533 T534 L323 T324 T325 T326 S329 W374 R381 G406 R408 P409 G410 S411 Y413 T414
BS02 OXL G K282 E284 A305 G307 D308 T340 K162 E164 A185 G187 D188 T220
BS03 MG G E284 D308 E164 D188
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003824 catalytic activity
GO:0004743 pyruvate kinase activity
GO:0030955 potassium ion binding
Biological Process
GO:0006096 glycolytic process

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Molecular Function
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Biological Process
External links
PDB RCSB:5sca, PDBe:5sca, PDBj:5sca
PDBsum5sca
PubMed35290845
UniProtP30613|KPYR_HUMAN Pyruvate kinase PKLR (Gene Name=PKLR)

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