Structure of PDB 5mcp Chain G

Receptor sequence
>5mcpG (length=382) Species: 284811 (Eremothecium gossypii ATCC 10895) [Search protein sequence]
YRDAATALEHLATYAEKDGLSVEQLMDSKTRTYNDFLVLPGKIDFPSSEV
VLSSRLTKKITLNAPFVSSPMDTVTEADMAIHMALLGGIGIIHHNCTAEE
QAEMVRRVKKYENGFATVADVRRMKNEFGFAGFPVGKPTGKLQGIITSRD
IQFVEETLLVSEIMTKDVITLEEANQILKNTKKGKLPISRSYPLASKSTK
QLLCGAAIGIDADRQRLAMLVEAGLDVVVLDSSGNSVFQINMIKWIKETF
PDLQVIAGNVVTREQAASLIHAGADGLRIGMGRPQGTAVYNVTQFANQFG
VPCIADGGVQNIGHITKAIALGASTVMMGGMGTTESPKGSIKKYIPYLYN
GLQHSCQDIGVRSLVEFREKVDSGSVRFEFRT
3D structure
PDB5mcp A nucleotide-controlled conformational switch modulates the activity of eukaryotic IMP dehydrogenases.
ChainG
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.205: IMP dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP G T165 S166 R167 D168 T184 V187 I188 G209 K210 T147 S148 R149 D150 T165 V168 I169 G184 K185
BS02 ATP G F145 G147 S166 F130 G132 S148
BS03 ATP G S278 S279 S232 S233
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003824 catalytic activity
GO:0003938 IMP dehydrogenase activity
GO:0005524 ATP binding
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
Biological Process
GO:0006164 purine nucleotide biosynthetic process
GO:0006177 GMP biosynthetic process
GO:0006183 GTP biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5mcp, PDBe:5mcp, PDBj:5mcp
PDBsum5mcp
PubMed28572600
UniProtQ756Z6

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