Structure of PDB 5ldx Chain G

Receptor sequence

>5ldxG (length=685) Species: 9913 (Bos taurus)

LIEVFVDGQSVMVEPGTTVLQACEKVGMQIPRFCYHERLSVAGNCRMCLV
EIEKAPKVVAACAMPVMKGWNILTNSEKTKKAREGVMEFLLANHPLDCPI
CDQGGECDLQDQSMMFGSDRSRFLEGKRAVEDKNIGPLVKTIMTRCIQCT
RCIRFASEIAGVDDLGTTGRGNDMQVGTYIEKMFMSELSGNIIDICPVGA
LTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

3D structure

• PDB: 5ldx Structure of mammalian respiratory complex I.
• Chain: G
• Resolution: 5.6 Å

Enzymatic activity

• Enzyme Commision number: 7.1.1.2: NADH:ubiquinone reductase (H(+)-translocating).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	SF4	G	H101 D104 C105 C108 Q110 C114 Q117 V205 G206	H94 D97 C98 C101 Q103 C107 Q110 V198 G199
BS02	SF4	G	C153 I154 C156 C159 C203	C146 I147 C149 C152 C196
BS03	FES	G	R39 F40 C41 G50 C52 C55 C69	R32 F33 C34 G43 C45 C48 C62

Gene Ontology

Molecular Function

• GO:0008137 NADH dehydrogenase (ubiquinone) activity
• GO:0016491 oxidoreductase activity
• GO:0051536 iron-sulfur cluster binding

Biological Process

• GO:0042773 ATP synthesis coupled electron transport

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:5ldx, PDBe:5ldx, PDBj:5ldx
• PDBsum: 5ldx
• PubMed: 27509854
• UniProt: P15690|NDUS1_BOVIN NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial (Gene Name=NDUFS1)