Structure of PDB 5iz0 Chain G

Receptor sequence
>5iz0G (length=246) Species: 9606 (Homo sapiens) [Search protein sequence]
PYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKS
MWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVL
VRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHF
SEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSI
LAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFST
3D structure
PDB5iz0 Structural determinant for inducing RORgamma specific inverse agonism triggered by a synthetic benzoxazinone ligand.
ChainG
Resolution2.635 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide G I492 Q495 I230 Q233
BS02 peptide G K336 L353 K354 P500 L501 E504 K74 L91 K92 P238 L239 E242
BS03 6F1 G C320 H323 L324 M365 V376 F388 I400 H479 C58 H61 L62 M103 V114 F126 I138 H217
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5iz0, PDBe:5iz0, PDBj:5iz0
PDBsum5iz0
PubMed27246200
UniProtP51449|RORG_HUMAN Nuclear receptor ROR-gamma (Gene Name=RORC)

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