Structure of PDB 5iud Chain G

Receptor sequence
>5iudG (length=863) Species: 9606 (Homo sapiens) [Search protein sequence]
EQVFHFYWLDAYEDQYNQPGVVFLFGKVWIESAETHVSCCVMVKNIERTL
YFLPREMKIDLNTGKETGTPISMKDVYEEFDEKIATKYKIMKFKSKPVEK
NYAFEIPDVPEKSEYLEVKYSAEMPQLPQDLKGETFSHVFGTNTSSLELF
LMNRKIKGPCWLEVKSPQLLNQPVSWCKVEAMALKPDLVNVIKDVSPPPL
VVMAFSMKTMQNAKNHQNEIIAMAALVHHSFALDKAAPKPPFQSHFCVVS
KPKDCIFPYAFKEVIEKKNVKVEVAATERTLLGFFLAKVHKIDPDIIVGH
NIYGFELEVLLQRINVCKAPHWSKIGRLKRSNMPKLGGGFGERNATCGRM
ICDVEISAKELIRCKSYHLSELVQQILKTERVVIPMENIQNMYSESSQLL
YLLEHTWKDAKFILQIMCELNVLPLALQITNIAGNIMSRTLMGGRSERNE
FLLLHAFYENNYIVPDKQIAYAGGLVLDPKVGFYDKFILLLDFNSLYPSI
IQEFNICFTTVQRQEQIPELPDPSLEMGILPREIRKLVERRKQVKQLMKQ
QDLNPDLILQYDIRQKALKLTANSMYGCLGFSYSRFYAKPLAALVTYKGR
EILMHTKEMVQKMNLEVIYGDTDSIMINTNSTNLEEVFKLGNKVKSEVNK
LYKLLEIDIDGVFKSLLLLKKKKYAALVVEPTSDGNYVTKQELKGLDIVR
RDWCDLAKDTGNFVIGQILSDQSRDTIVENIQKRLIEIGENVLNGSVPVS
QFEINKALTKDPQDYPDKKSLPHVHVALWINSQGGRKVKAGDTVSYVICQ
DGSNLTASQRAYAPEQLQKQDNLTIDTQYYLAQQIHPVVARICEPIDGID
AVLIATWLGLDPT
3D structure
PDB5iud Human DNA polymerase alpha in binary complex with a DNA:DNA template-primer.
ChainG
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna G G675 G783 R784 S785 Y839 G841 V844 G961 F962 K1052 S1189 R1222 G338 G444 R445 S446 Y471 G473 V476 G580 F581 K671 S808 R841
BS02 dna G D1002 G1076 R1081 R1082 K1137 A1138 Y1146 H1154 D621 G695 R700 R701 K756 A757 Y765 H773
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:1902975 mitotic DNA replication initiation

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Molecular Function
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Biological Process
External links
PDB RCSB:5iud, PDBe:5iud, PDBj:5iud
PDBsum5iud
PubMed27032819
UniProtP09884|DPOLA_HUMAN DNA polymerase alpha catalytic subunit (Gene Name=POLA1)

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