Structure of PDB 5hn7 Chain G

Receptor sequence
>5hn7G (length=346) Species: 126793 (Plasmodium vivax Sal-1) [Search protein sequence]
LAFFRNMYDKYRDAFLSHLNEYSLEEEIKEHISKYYKLLFDYNCLGGKNN
RGILVILIYEYVKNSSEWEKAACLAWCIEILQAAFLVADDIMDKGEMRRN
KYCWYLLKDVETKNAVNDVLLLYNSIYKLIEIYLRNESCYVDVIATFRDA
TLKTIIGQHLDTNIFSDKYSIDVNNINPVIDINMINFGVYKNIVIHKTAY
YSFFLPIVCGMLLAGIDNLIYKKIEDISMLMGEYFQIHDDYLDIFGDSTK
TGKVSDIQNNKLTWPLIKTFELCSEPDKIKIVKNYGKNNLACVKVIDSLY
EQYKIRKHYESYEKAQKAKILSAINELHHEGIEYVLKYLLEILFTG
3D structure
PDB5hn7 Dynamic Structure and Inhibition of a Malaria Drug Target: Geranylgeranyl Diphosphate Synthase.
ChainG
Resolution2.15 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K81 A121 D126 D130 R135 D198 K243 F283 D287 D288
Catalytic site (residue number reindexed from 1) K48 A84 D89 D93 R98 D161 K197 F235 D239 D240
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 04M G N154 L157 N117 L120 MOAD: ic50=120uM
BS02 04M G G80 K81 R84 Q119 F122 M129 R135 R136 Q195 K243 T244 Y247 F283 G47 K48 R51 Q82 F85 M92 R98 R99 Q158 K197 T198 Y201 F235 MOAD: ic50=120uM
Gene Ontology
Molecular Function
GO:0004161 dimethylallyltranstransferase activity
GO:0004337 geranyltranstransferase activity
GO:0004659 prenyltransferase activity
GO:0016740 transferase activity
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
GO:0046872 metal ion binding
Biological Process
GO:0008299 isoprenoid biosynthetic process
GO:0045337 farnesyl diphosphate biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5hn7, PDBe:5hn7, PDBj:5hn7
PDBsum5hn7
PubMed27564465
UniProtA5K4U6

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