Structure of PDB 5f9f Chain G

Receptor sequence

>5f9fG (length=669) Species: 9606 (Homo sapiens) [Search protein sequence]

PFKPRNYQLELALPAMKGKNTIICAPTGCGKTFVSLLICEHHLKKFPQGQ
KGKVVFFANQIPVYEQQKSVFSKYFERHGYRVTGISGATAENVPVEQIVE
NNDIIILTPQILVNNLKKGTIPSLSIFTLMIFDECHNTSKQHPYNMIMFN
YLDQKLGGSSGPLPQVIGLTASVGVGDAKNTDEALDYICKLCASLDASVI
ATVKHNLEELEQVVYKPQKFFRKVESRISDKFKYIIAQLMRDTESLAKRI
CKREFGTQKYEQWIVTVQKACMVFQMPDKDEESRICKALFLYTSHLRKYN
DALIISEHARMKDALDYLKDFFSNVRAAGFDEIEQDLTQRFEEKLQELES
VSRDPSNENPKLEDLCFILQEEYHLNPETITILFVKTRALVDALKNWIEG
NPKLSFLKPGILTGRGKTNQNTGMTLPAQKCILDAFKASGDHNILIATSV
ADEGIDIAQCNLVILYEYVGNVIKMIQTRGRGRARGSKCFLLTSNAGVIE
KEQINMYKEKMMNDSILRLQTWDEAVFREKILHIQTHEKFIRDSQPVPDK
ENKKLLCRKCKALACYTADVRVIEECHYTVLGDAFKECFVSRPHPKPKQF
SSFEKRAKIFCARQNCSHDWGIHVKYKTFEIPVIKIESFVVEDIATGVQT
LYSKWKDFHFEKIPFDPAE

3D structure

PDB

5f9f Structural basis for m7G recognition and 2'-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-I.

Chain

Resolution

2.601 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.6.4.13: RNA helicase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	G	N298 Q299 I300 S325 G326 T347 Q349 K379 Q380 Q507 K508 E510 Q511 R546 K635 T636 R637 T662 G663 R664 T667 N668 T697 S698 K750 H830 F853 K858 I875 V886 K888 W908 K909	N59 Q60 I61 S86 G87 T108 Q110 K140 Q141 Q258 K259 E261 Q262 R297 K386 T387 R388 T413 G414 R415 T418 N419 T448 S449 K501 H577 F600 K605 I622 V633 K635 W655 K656	PDBbind-CN: Kd=38.5nM
BS02	ZN	G	C810 C864 C869	C557 C611 C616
BS03	BU3	G	I262 A264 C268 K270 T409	I23 A25 C29 K31 T170
BS04	BU3	G	A329 E330 I350 N353 N354	A90 E91 I111 N114 N115
BS05	BU3	G	L714 Y717 G719 K723	L465 Y468 G470 K474

Gene Ontology

	Molecular Function
GO:0003676	nucleic acid binding
GO:0005524	ATP binding

View graph for
Molecular Function

External links

PDB	RCSB:5f9f, PDBe:5f9f, PDBj:5f9f
PDBsum	5f9f
PubMed	26733676
UniProt	O95786\|RIGI_HUMAN Antiviral innate immune response receptor RIG-I (Gene Name=RIGI)

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