Structure of PDB 5ey8 Chain G

Receptor sequence
>5ey8G (length=597) Species: 1772 (Mycolicibacterium smegmatis) [Search protein sequence]
GQIKFPDGSSIVAHVERWAKVRGDKLAYRFLDFSTERDGVPRDLTWAQFS
ARNRAVAARLQQVTQPGDRVAILCPQNLDYLVAFFGALYAGRIAVPLFDP
SEPHVGRLHAVLDNCHPSAILTTTEAAEGVRKFFRTRPANQRPRVIAVDA
VPDDVASTWVNPDEPDETTIAYLQYTTRIPTGVQITHLNLATNVVQVIEA
LEGEEGDRGLSWLPFFHDMGLITALLAPMIGHYFTFMTPAAFVRRPERWI
RELKEGDTGGTISVAPNFAFDHAAARGVPKPGSPPLDLSNVKAVLNGSEP
ISAATVRRFNEAFGPFGFPPKAIKPSYGLAEATLFVSTTPSAEEPKIITV
DRDQLNSGRIVEVDADSPKAVAQASAGKVGIAEWAVIVDAEATELPDGQV
GEIWISGQNMGTGYWGKPEESVATFQNILKSRTNPSHAEGATDDATWVRT
GDYGAFYDGDLYITGRVKDLVIIDGRNHYPQDLEYSAQEASKAIRTGYVA
AFSVPANQLPDEVFENAHSGIKRDPDDTSEQLVIVAERAPDIGPITDDIR
AAIAVRHGVTVRDVLLTAAGAIPRTSSGKIGRRACRAAYLDGSLRAG
3D structure
PDB5ey8 Insight into Structure-Function Relationships and Inhibition of the Fatty Acyl-AMP Ligase (FadD32) Orthologs from Mycobacteria.
ChainG
Resolution3.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N207 H231 A346
Catalytic site (residue number reindexed from 1) N193 H217 A330
Enzyme Commision number 6.2.1.20: long-chain-fatty-acid--[acyl-carrier-protein] ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5SV G H231 D232 M233 L311 S314 P316 I317 S342 Y343 G344 L345 L350 D469 I480 H217 D218 M219 L295 S298 P300 I301 S326 Y327 G328 L329 L334 D452 I463
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0008922 long-chain fatty acid [acyl-carrier-protein] ligase activity
GO:0016874 ligase activity
GO:0070566 adenylyltransferase activity
Biological Process
GO:0006631 fatty acid metabolic process
GO:0006633 fatty acid biosynthetic process
GO:0008610 lipid biosynthetic process
Cellular Component
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5ey8, PDBe:5ey8, PDBj:5ey8
PDBsum5ey8
PubMed26900152
UniProtA0R618|FAA32_MYCS2 Long-chain-fatty-acid--AMP ligase FadD32 (Gene Name=fadD32)

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