Structure of PDB 5ebu Chain G

Receptor sequence
>5ebuG (length=367) Species: 1377 (Aerococcus viridans) [Search protein sequence]
YNAPSEIKYIDVVNTYDLEEEASKVVPHGGFNYIAGASGDEWTKRANDRA
WKHKLLYPRLAQDVEAPDTSTEILGHKIKAPFIMAPIAAHGLAHATKEAG
TARAVSEFGTIMSISAYSGATFEEISEGLNGGPRWFQIYMAKDDQQNRDI
LDEAKGDGATAIILTADSTVSGNRDRDVKNKFVYPFGMPIVQRYLRGTAE
GMSLNNIFGASKQKISPRDIEEIAAHSGLPVFVKGIQHPEDADMAIKAGA
SGIWVSNHGARQLYEAPGSFDTLPAIAERVNKRVPIVFDSGVRRGEHVAK
ALASGADVVALGRPVLFGLALGGWQGAYSVLDYFQKDLTRVMQLTGSQNV
EDLKGLDLFDNPYGYEY
3D structure
PDB5ebu Conformational flexibility related to enzyme activity: evidence for a dynamic active-site gatekeeper function of Tyr(215) in Aerococcus viridans lactate oxidase.
ChainG
Resolution2.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S122 Y146 T172 D174 K241 H265
Catalytic site (residue number reindexed from 1) S115 Y139 T165 D167 K234 H258
Enzyme Commision number 1.1.3.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FMN G P93 I94 A95 S122 Q144 Y146 T172 K241 H265 G266 R268 D296 S297 G298 R300 G319 R320 P86 I87 A88 S115 Q137 Y139 T165 K234 H258 G259 R261 D289 S290 G291 R293 G312 R313
BS02 PYR G Y40 Y146 R181 H265 R268 Y33 Y139 R174 H258 R261
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004459 L-lactate dehydrogenase activity
GO:0010181 FMN binding
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:5ebu, PDBe:5ebu, PDBj:5ebu
PDBsum5ebu
PubMed27302031
UniProtQ44467|LOX_AERVM L-lactate oxidase

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