Structure of PDB 4tuh Chain G

Receptor sequence
>4tuhG (length=141) Species: 9606 (Homo sapiens) [Search protein sequence]
SMSQSNRELVVDFLSYKLSQKGYSWSQMAAVKQALREAGDEFELRYRRAF
SDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESV
DKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYG
3D structure
PDB4tuh Structure-Guided Rescaffolding of Selective Antagonists of BCL-XL.
ChainG
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 38H G E96 F97 Y101 R102 F105 S106 L108 T109 L130 N136 G138 R139 A142 S145 F146 A149 L194 Y195 E41 F42 Y46 R47 F50 S51 L53 T54 L75 N81 G83 R84 A87 S90 F91 A94 L139 Y140 BindingDB: Ki=0.380000nM,EC50=60nM
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:4tuh, PDBe:4tuh, PDBj:4tuh
PDBsum4tuh
PubMed24944740
UniProtQ07817|B2CL1_HUMAN Bcl-2-like protein 1 (Gene Name=BCL2L1)

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