Structure of PDB 4p0s Chain G

Receptor sequence
>4p0sG (length=275) Species: 9606 (Homo sapiens) [Search protein sequence]
QQQPLELRPGEYRVLLCVDIGETRGPELLRELQRLHVTHTVRKLHVGDFV
WVAQETNPRDPANPGELVLDHIVERKRLDDLCSSIIDGRFREQKFRLKRC
GLERRVYLVEEHGSVHNLSLPESTLLQAVTNTQVIDGFFVKRTADIKESA
AYLALLTRGLQRLYQGHTLRSRPWGTPGPNPLCSLLTFSDFNAGAREVFA
RQLMQVRGVSGEKAAALVDRYSTPASLLAAYDACATPKEQETLLSTIKCG
RLQRNLGPALSRTLSQLYCSYGPLT
3D structure
PDB4p0s Crystal structures of the structure-selective nuclease Mus81-Eme1 bound to flap DNA substrates.
ChainG
Resolution6.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.22.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna G R350 N531 P534 R91 N255 P258
BS02 dna G R279 R483 G484 V485 S486 K489 R527 R530 R24 R207 G208 V209 S210 K213 R251 R254
BS03 dna G E277 D339 E22 D80
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004518 nuclease activity
GO:0008821 crossover junction DNA endonuclease activity
Biological Process
GO:0006302 double-strand break repair
GO:0006308 DNA catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4p0s, PDBe:4p0s, PDBj:4p0s
PDBsum4p0s
PubMed24733841
UniProtQ96NY9|MUS81_HUMAN Crossover junction endonuclease MUS81 (Gene Name=MUS81)

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