Structure of PDB 4nod Chain G

Receptor sequence

>4nodG (length=190) Species: 9606 (Homo sapiens) [Search protein sequence]

SVLASCPKKPVSSYLRFSKEQLPIFKAQNPDAKTTELIRRIAQRWRELPD
SKKKIYQDAYRAEWQVYKEEISRFKEQLTPSQIMSLEKEIMDKHLKRKAM
TKKKELTLLGKPKRPRSAYNVYVAERFQEAKGDSPQEKLKTVKENWKNLS
DSEKELYIQHAKEDETRYHNEMKSWEEQMIEVGRKDLLRR

3D structure

PDB

4nod Distinct structural features of TFAM drive mitochondrial DNA packaging versus transcriptional activation.

Chain

Resolution

2.897 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	G	L58 L65 T77 R140 M143 K146 Y162 Q179 L182 K186 W189 E208	L15 L22 T34 R97 M100 K103 Y119 Q136 L139 K143 W146 E165	PDBbind-CN: Kd=7.1nM
BS02	dna	G	K52 S55 Y57 T78 A85 R89 Y103 W107 R140 M143 K156 R157 N163 V166 A167 F170 P178	K9 S12 Y14 T35 A42 R46 Y60 W64 R97 M100 K113 R114 N120 V123 A124 F127 P135	PDBbind-CN: Kd=7.1nM

External links

PDB	RCSB:4nod, PDBe:4nod, PDBj:4nod
PDBsum	4nod
PubMed	24435062
UniProt	Q00059\|TFAM_HUMAN Transcription factor A, mitochondrial (Gene Name=TFAM)

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