Structure of PDB 4nnd Chain G

Receptor sequence
>4nndG (length=278) Species: 9606 (Homo sapiens) [Search protein sequence]
DSARSFLERLVLAGEFSDIQACSAAWKADGVCSTVAGSRPENVRKNRYKD
VLPYDQTRVILSLLQEEHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDF
WRLVWEFGVKVILMACREIENGRKRCERYWAQEQEPLQTGLFCITLIKEK
WLNEDIMLRTLKVTFQKESRSVYQLQYMSWPDRGVPSPDHMLAMVEEARR
LQGSGPEPLCVHSSAGCGRTGVLCTVDYVRQLLLTQMIPPDFSLFDVVLK
MRKQRPAAVQTEEQYRFLYHTVAQMFCS
3D structure
PDB4nnd Large-scale structural analysis of the classical human protein tyrosine phosphatome.
ChainG
Resolution2.502 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D197 S229 R235 T236 Q276
Catalytic site (residue number reindexed from 1) D182 S213 R219 T220 Q260
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide G Y62 D64 R138 D197 S229 S230 A231 C233 R235 Q276 Y48 D50 R123 D182 S213 S214 A215 C217 R219 Q260
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
GO:0004726 non-membrane spanning protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4nnd, PDBe:4nnd, PDBj:4nnd
PDBsum4nnd
PubMed
UniProtQ99952|PTN18_HUMAN Tyrosine-protein phosphatase non-receptor type 18 (Gene Name=PTPN18)

[Back to BioLiP]