Structure of PDB 4nb4 Chain G

Receptor sequence
>4nb4G (length=265) Species: 282458 (Staphylococcus aureus subsp. aureus MRSA252) [Search protein sequence]
MKVGIDAGGTLIKIVQEQDNQRTFKTELTKNIDQVVEWLNQQQIEKLCLT
GGNAGVIAENINIPAQIFVEFDAASQGLGILLKEQGHDLADYIFANVGTG
TSLHYFDGQSQRRVGGIGTGGGMIQGLGYLLSQITDYKQLTDMAQHGDRN
TIDLKVRHIYTEPPIPGDLTAANFGHVLHHLDADFTPSNKLAAVIGVVGE
VVTTMAITVAREFKTENIVYIGSSFHNNALLRKVVEDYTVLRGCKPYYVE
NGAFSGAIGALYLEK
3D structure
PDB4nb4 Structural characterization of a new N-substituted pantothenamide bound to pantothenate kinases from Klebsiella pneumoniae and Staphylococcus aureus.
ChainG
Resolution2.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.33: pantothenate kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP G G8 G9 T10 L11 K13 G98 T99 G121 Q125 Y137 S225 S226 G8 G9 T10 L11 K13 G98 T99 G121 Q125 Y137 S223 S224
BS02 SH3 G F71 G100 T101 R113 G116 I117 F71 G100 T101 R113 G116 I117
BS03 SH3 G L171 T172 A173 E202 Y240 L169 T170 A171 E200 Y238
Gene Ontology
Molecular Function
GO:0004594 pantothenate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
Biological Process
GO:0015937 coenzyme A biosynthetic process
GO:0016310 phosphorylation
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:4nb4, PDBe:4nb4, PDBj:4nb4
PDBsum4nb4
PubMed24470271
UniProtQ6G7I0|COAW_STAAS Type II pantothenate kinase (Gene Name=coaW)

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