Structure of PDB 4l8w Chain G

Receptor sequence
>4l8wG (length=287) Species: 7955 (Danio rerio) [Search protein sequence]
KTNERPIIGVLAQDVFDPKPDRNSYIAASYVKFLESAGARVVPVMINKSE
DEYSRLFKSINGVLFPGGGVSLESSGYSKAAGIFYRLALEANSNGDYFPV
WGTCLGFELLTLLTSGELLLSHTNTSGIALPLDFTEDVKGSRLFKEFPEE
LMKSLATEPLTENSHQWSITTENFTANKKLKKFYRVLSTNTDGYNKFVST
MEAYDFPIYATQWNPEKNAFEWTRPYIPHTPSAIKTTFYMANFFVNEARK
NLHSFASTEEEEKALIYNYKPEYTGIQSAFEQTYFFN
3D structure
PDB4l8w Structural insights into the hydrolysis and polymorphism of methotrexate polyglutamate by zebrafish gamma-glutamyl hydrolase
ChainG
Resolution2.39 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E220
Catalytic site (residue number reindexed from 1) E216
Enzyme Commision number 3.4.19.9: folate gamma-glutamyl hydrolase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MTX G F20 G71 G72 G73 C108 L109 E112 H169 Q170 W171 F16 G67 G68 G69 C104 L105 E108 H165 Q166 W167
BS02 DGL G G72 S168 K221 G68 S164 K217
BS03 DGL G S282 F284 S278 F280
Gene Ontology
Molecular Function
GO:0008242 omega peptidase activity
GO:0016787 hydrolase activity

View graph for
Molecular Function
External links
PDB RCSB:4l8w, PDBe:4l8w, PDBj:4l8w
PDBsum4l8w
PubMed24028568
UniProtQ6NY42

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