Structure of PDB 4ig9 Chain G

Receptor sequence
>4ig9G (length=270) Species: 9606 (Homo sapiens) [Search protein sequence]
MRKKRKDINTIEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYAR
LAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIAL
SDKEGKLLRNYTQNIDTLEQVAGIQRIIQCHGSFATASCLICKYKVDCEA
VRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDKDE
VDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLGDC
DVIINELCHRLGGEYAKLCC
3D structure
PDB4ig9 Structural and Functional Analysis of Human SIRT1.
ChainG
Resolution2.64 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) P271 D272 F273 R274 N346 D348 H363
Catalytic site (residue number reindexed from 1) P39 D40 F41 R42 N114 D116 H131
Enzyme Commision number 2.3.1.-
2.3.1.286: protein acetyllysine N-acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide G K236 N241 T242 I243 R466 P468 D475 E477 L479 G480 D481 I485 E488 R492 K4 N9 T10 I11 R234 P236 D243 E245 L247 G248 D249 I253 E256 R260
BS02 ZN G C371 C395 C398 C139 C163 C166
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:4ig9, PDBe:4ig9, PDBj:4ig9
PDBsum4ig9
PubMed24120939
UniProtQ96EB6|SIR1_HUMAN NAD-dependent protein deacetylase sirtuin-1 (Gene Name=SIRT1)

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