Structure of PDB 4e7r Chain G

Receptor sequence

>4e7rG (length=250) Species: 9606 (Homo sapiens) [Search protein sequence]

IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETGQP
SVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGG
PFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF

3D structure

PDB

4e7r New 3-amidinophenylalanine-derived inhibitors of matriptase

Chain

Resolution

2.25 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

3.4.21.5: thrombin.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	G	E1023 I1024 G1025 M1026 P1028 W1029 D1116 H1119 P1120 C1122 Y1134 K1135 R1137 N1159 M1201 K1202 N1205 R1206 W1207	E8 I9 G10 M11 P13 W14 D113 H116 P117 C119 Y134 K135 R137 N157 M204 K205 N210 R211 W212
BS02	peptide	G	F1034 Q1038 L1065 R1067 R1073 T1074 Y1076 K1081 I1082	F19 Q24 L60 R62 R68 T69 Y71 K77 I78
BS03	0NW	G	H1057 Y1060A W1060D N1098 L1099 D1189 A1190 C1191 E1192 S1195 V1213 W1215 G1216 E1217 G1219	H43 Y47 W50 N95 L96 D192 A193 C194 E195 S198 V218 W220 G221 E222 G223

Gene Ontology

	Molecular Function
GO:0004252	serine-type endopeptidase activity
GO:0005509	calcium ion binding

	Biological Process
GO:0006508	proteolysis
GO:0007596	blood coagulation

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:4e7r, PDBe:4e7r, PDBj:4e7r
PDBsum	4e7r
PubMed
UniProt	P00734\|THRB_HUMAN Prothrombin (Gene Name=F2)

[Back to BioLiP]