Structure of PDB 4dpw Chain G

Receptor sequence
>4dpwG (length=326) Species: 1282 (Staphylococcus epidermidis) [Search protein sequence]
MVKSGKARAHTNIALIKYWGKADETYIIPMNNSLSVTLDRFYTETKVTFD
PDFTEDCLILNGNEVNAKEKEKIQNYMNIVRDLAGNRLHARIESENYVPT
AAGLASSASAYAALAAACNEALSLNLSDTDLSRLARRGSGSASRSIFGGF
AEWEKGHDDLTSYAHGINSNGWEKDLSMIFVVINNQSKKVSSRSGMSLTR
DTSRFYQYWLDHVDEDLNEAKEAVKNQDFQRLGEVIEANGLRMHATNLGA
QPPFTYLVQESYDAMAIVEQCRKANLPCYFTMAAGPNVKVLVEKKNKQAV
MEQFLKVFDESKIIASDIISSGVEII
3D structure
PDB4dpw Structural basis for nucleotide binding and reaction catalysis in mevalonate diphosphate decarboxylase.
ChainG
Resolution2.605 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 4.1.1.33: diphosphomevalonate decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AGS G L60 E69 K72 S94 N96 A101 G103 A105 S106 S107 A110 K188 S192 L60 E69 K72 S94 N96 A101 G103 A105 S106 S107 A110 K188 S192
BS02 DP6 G A14 Y18 K21 S139 G140 S141 R144 S192 R193 M196 A14 Y18 K21 S139 G140 S141 R144 S192 R193 M196
Gene Ontology
Molecular Function
GO:0004163 diphosphomevalonate decarboxylase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016829 lyase activity
GO:0016831 carboxy-lyase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0008299 isoprenoid biosynthetic process
GO:0016310 phosphorylation
GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway
Cellular Component
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4dpw, PDBe:4dpw, PDBj:4dpw
PDBsum4dpw
PubMed22734632
UniProtQ9FD73

[Back to BioLiP]