Structure of PDB 4d0m Chain G

Receptor sequence
>4d0mG (length=470) Species: 9606 (Homo sapiens) [Search protein sequence]
SWLLRLFESKLFDISMAISYLYNSKEPGVQAYIGNRLFCFRNEDVDFYLP
QLLNMYIHMDEDVGDAIKPYIVHRCRQSINFSLQCALLLGAYSSRGTKLR
KLILSRLAPEREFIKSLMAIGKRLATLPTKEQKTQRLISELSLLNHKLPA
RVWLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLECENFDTTSVP
ARIPENPSAVALKEPWQEKVRRIREGSPYGHLPNWRLLSVIVKCGDDLRQ
ELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAVSIHQ
VKKQSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKD
RHNGNILLDAEGHIIHIDFGFILSSSSAFKLTTEFVDVMGGLDGDMFNYY
KMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMS
MTEEQLQLLVEQMVDGSMRS
3D structure
PDB4d0m Structures of Pi4Kiiibeta Complexes Show Simultaneous Recruitment of Rab11 and its Effectors.
ChainG
Resolution6.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.67: 1-phosphatidylinositol 4-kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 093 G I547 K549 I595 P597 V598 A601 L663 I673 D674 I241 K243 I289 P291 V292 A295 L357 I367 D368 BindingDB: IC50=19nM
Gene Ontology
Molecular Function
GO:0016301 kinase activity
Biological Process
GO:0046854 phosphatidylinositol phosphate biosynthetic process

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4d0m, PDBe:4d0m, PDBj:4d0m
PDBsum4d0m
PubMed24876499
UniProtQ9UBF8|PI4KB_HUMAN Phosphatidylinositol 4-kinase beta (Gene Name=PI4KB)

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