Structure of PDB 3zkb Chain G

Receptor sequence
>3zkbG (length=381) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
EYGAASITILEGLEAVRKRPGMYIGSTGERGLHHLIWEVVDNAVDEAMAG
YATTVNVVLLEDGGVEVADDGRGIPVATHASGIPTVDVVMTQLHAGGKFD
SDAYAISGGLHGVGVSVVNALSTRLEVEIKRDGYEWSQVYEKSEPLGLKQ
GAPTKKTGSTVRFWADPAVFETTEYDFETVARRLQEMAFLNKGLTINLTD
ERAPHKVKSRTFHYPGGLVDFVKHINRTKNAIHSSIVDFSGKGTGHEVEI
AMQWNAGYSESVHTFANTINTHEGGTHEEGFRSALTSVVNKYAKDRKLLD
PNLTGDDIREGLAAVISVKVSEPQFEGQTKTKLGNTEVKSFVQKVCNEQL
THWFEANPTDAKVVVNKAVSSAQARIAARKA
3D structure
PDB3zkb Mycobacterium Tuberculosis DNA Gyrase ATPase Domain Structures Suggest a Dissociative Mechanism that Explains How ATP Hydrolysis is Coupled to Domain Motion.
ChainG
Resolution2.9 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP G N52 E56 I84 V99 G106 G107 K108 Y114 G119 L120 H121 G122 V123 G124 V125 S169 Q370 K372 N42 E46 I74 V89 G96 G97 K98 Y104 G109 L110 H111 G112 V113 G114 V115 S159 Q328 K330
BS02 MG G D80 G81 T167 D70 G71 T157
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006265 DNA topological change

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3zkb, PDBe:3zkb, PDBj:3zkb
PDBsum3zkb
PubMed24015710
UniProtP9WG45|GYRB_MYCTU DNA gyrase subunit B (Gene Name=gyrB)

[Back to BioLiP]