Structure of PDB 3kl8 Chain G

Receptor sequence
>3kl8G (length=259) Species: 6239 (Caenorhabditis elegans) [Search protein sequence]
TKFSDNYDVKEESVVRRCVHKTTGLEFAAKIINTSARDFQKLEREARICR
KLQHPNIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHC
IQQILESIAYCHSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVND
SEAWHGFAGTPGYLSPEVLKKDPYSKPVDIWACGVILYILLVGYPPFWDE
DQHRLYAQIKAGAYDYPSPEWDTVTPEAKSLIDSMLTVNPKKRITADQAL
KVPWICNRE
3D structure
PDB3kl8 Intersubunit capture of regulatory segments is a component of cooperative CaMKII activation.
ChainG
Resolution3.372 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N135 K137 E139 N140 D156 T175
Catalytic site (residue number reindexed from 1) N120 K122 E124 N125 D141 T160
Enzyme Commision number 2.7.11.17: calcium/calmodulin-dependent protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide G E96 F98 N135 E139 D156 F172 A173 G174 P176 G208 P210 P211 W213 Y229 D230 P232 S233 E235 E81 F83 N120 E124 D141 F157 A158 G159 P161 G193 P195 P196 W198 Y214 D215 P217 S218 E220
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3kl8, PDBe:3kl8, PDBj:3kl8
PDBsum3kl8
PubMed20139983
UniProtO62305|KCC2D_CAEEL Calcium/calmodulin-dependent protein kinase type II (Gene Name=unc-43)

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