Structure of PDB 3khj Chain G

Receptor sequence
>3khjG (length=300) Species: 353152 (Cryptosporidium parvum Iowa II) [Search protein sequence]
TKNIGKGLTFEDILLVPNYSEVLPREVSLETKLTKNVSLKIPLISSAMDT
VTEHLMAVGMARLGGIGIIHKNMDMESQVNEVLKVKNSGGLRVGAAIGVN
EIERAKLLVEAGVDVIVLDSAHGHSLNIIRTLKEIKSKMNIDVIVGNVVT
EEATKELIENGADGIKVGIGPGTTRIVAGVGVPQITAIEKCSSVASKFGI
PIIADGGIRYSGDIGKALAVGASSVMIGSILAGTEESPGEKELIGDTVYK
YYEGRVKYKGEMEGVVYQLVGGLRSCMGYLGSASIEELWKKSSYVEITTS
3D structure
PDB3khj The structural basis of Cryptosporidium -specific IMP dehydrogenase inhibitor selectivity.
ChainG
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.205: IMP dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IMP G S48 G216 D252 G253 G275 S276 S46 G172 D205 G206 G228 S229
BS02 C64 G P26 G357 Y358 P24 G278 Y279
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0003938 IMP dehydrogenase activity
GO:0016491 oxidoreductase activity
Biological Process
GO:0006164 purine nucleotide biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:3khj, PDBe:3khj, PDBj:3khj
PDBsum3khj
PubMed20052976
UniProtQ5CPK7

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