Structure of PDB 3gyx Chain G

Receptor sequence
>3gyxG (length=662) Species: 879 (Megalodesulfovibrio gigas) [Search protein sequence]
KIPSKETPRGVAIAEPIIVEHSVDLLMVGGGMGNCGAAFEAVRWADKYAP
EAKILLVDKASLERSGAVAQGLSAINTYLGDNNADDYVRMVRTDLMGLVR
EDLIYDLGRHVDDSVHLFEEWGLPVWIKDEHGHNLDGAQAKAAGKSLRNG
DKPVRSGRWQIMINGESYKVIVAEAAKNALGQDRIIERIFIVKLLLDKNT
PNRIAGAVGFNLRANEVHIFKANAMVVACGGAVNVYRPRSVGEGMGRAWY
PVWNAGSTYTMCAQVGAEMTMMENRFVPARFKDGYGPVGAWFLLFKAKAT
NCKGEDYCATNRAMLKPYEERGYAKGHVIPTCLRNHMMLREMREGRGPIY
MDTKTALQTSFATMSPAQQKHLEAEAWEDFLDMCVGQANLWAATNCAPEE
RGSEIMPTEPYLLGSHSGCCGIWASGPDEAWVPEDYKVRAANGKVYNRMT
TVEGLWTCADGVGASGHKFSSGSHAEGRIVGKQMVRWYLDHKDFKPEFVE
TAEELKTLIYRPYYNYEKGKGASTCPVVNPEYISPKNFMMRLIKCTDEYG
GGVGTYYNTSKALLDTGFWLMEMLEEDSLKLAARDLHELLRCWENYHRLW
TVRLHMQHIAFREESRYPGFYYRADFLGLDDSKWKCFVNSKYDPAKKETK
IFKKPYYQIIPD
3D structure
PDB3gyx Crystal structure of Adenylylsulfate reductase from Desulfovibrio gigas suggests a potential self-regulation mechanism involving the C terminus of the beta-subunit
ChainG
Resolution3.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N78 S158 W251 R282 D381 H418 S472
Catalytic site (residue number reindexed from 1) N76 S156 W249 R280 D379 H416 S470
Enzyme Commision number 1.8.99.2: adenylyl-sulfate reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD G G31 G33 M34 G35 D60 K61 S67 G68 A69 L74 A76 I77 N78 F192 I193 C231 W251 Y252 S259 M385 S417 A461 D462 F471 S472 S475 G29 G31 M32 G33 D58 K59 S65 G66 A67 L72 A74 I75 N76 F190 I191 C229 W249 Y250 S257 M383 S415 A459 D460 F469 S470 S473
Gene Ontology
Molecular Function
GO:0000104 succinate dehydrogenase activity
GO:0000166 nucleotide binding
GO:0005515 protein binding
GO:0009055 electron transfer activity
GO:0009973 adenylyl-sulfate reductase activity
GO:0016491 oxidoreductase activity
GO:0046982 protein heterodimerization activity
GO:0050660 flavin adenine dinucleotide binding
GO:0071949 FAD binding
Biological Process
GO:0009061 anaerobic respiration
GO:0019420 dissimilatory sulfate reduction
GO:0051290 protein heterotetramerization
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3gyx, PDBe:3gyx, PDBj:3gyx
PDBsum3gyx
PubMed19820092
UniProtT2G6Z9|APRA_MEGG1 Adenylylsulfate reductase subunit alpha (Gene Name=aprA)

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