Structure of PDB 3cm2 Chain G

Receptor sequence
>3cm2G (length=102) Species: 9606 (Homo sapiens) [Search protein sequence]
TNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHC
GGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLV
RT
3D structure
PDB3cm2 Targeting the X-linked inhibitor of apoptosis protein through 4-substituted azabicyclo[5.3.0]alkane smac mimetics. Structure, activity, and recognition principles.
ChainG
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 X23 G H346 E349 H93 E96 MOAD: Ki=340nM
BindingDB: IC50=110nM
BS02 ZN G C300 C303 H320 C327 C47 C50 H67 C74
BS03 X23 G L292 K297 G306 L307 T308 D309 W310 E314 W323 L39 K44 G53 L54 T55 D56 W57 E61 W70 MOAD: Ki=340nM
BindingDB: IC50=110nM
External links
PDB RCSB:3cm2, PDBe:3cm2, PDBj:3cm2
PDBsum3cm2
PubMed18851976
UniProtP98170|XIAP_HUMAN E3 ubiquitin-protein ligase XIAP (Gene Name=XIAP)

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