Structure of PDB 3blw Chain G

Receptor sequence
>3blwG (length=329) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
GRFTVTLIPGDGVGKEITDSVRTIFEAENIPIDWETINIKEGVYEAVESL
KRNKIGLKGLWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGVKTRI
PDIDLIVIRENTEGEFSGLEHESVPGVVESLKVMTRPKTERIARFAFDFA
KKYNRKSVTAVHKANIMKLGDGLFRNIITEIGQKEYPDIDVSSIIVDNAS
MQAVAKPHQFDVLVTPSMYGTILGNIGAALIGGPGLVAGANFGRDYAVFE
PGSRHVGLDIKGQNVANPTAMILSSTLMLNHLGLNEYATRISKAVHETIA
EGKHTTRDIGGSSSTTDFTNEIINKLSTM
3D structure
PDB3blw Allosteric Motions in Structures of Yeast NAD+-specific Isocitrate Dehydrogenase.
ChainG
Resolution4.3 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) F136 K183 D217 T241 N245
Catalytic site (residue number reindexed from 1) F116 K163 D197 T221 N225
Enzyme Commision number 1.1.1.41: isocitrate dehydrogenase (NAD(+)).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FLC G T83 S92 V95 R98 R129 F136 T241 R274 T63 S72 V75 R78 R109 F116 T221 R254
BS02 AMP G H275 G277 N287 D328 H255 G257 N267 D308
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003723 RNA binding
GO:0004449 isocitrate dehydrogenase (NAD+) activity
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0046872 metal ion binding
GO:0051287 NAD binding
Biological Process
GO:0006099 tricarboxylic acid cycle
GO:0006102 isocitrate metabolic process
GO:0006537 glutamate biosynthetic process
Cellular Component
GO:0005739 mitochondrion
GO:0005758 mitochondrial intermembrane space
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
GO:0042645 mitochondrial nucleoid
GO:0045242 isocitrate dehydrogenase complex (NAD+)

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3blw, PDBe:3blw, PDBj:3blw
PDBsum3blw
PubMed18256028
UniProtP28834|IDH1_YEAST Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial (Gene Name=IDH1)

[Back to BioLiP]