Structure of PDB 3a2c Chain G

Receptor sequence
>3a2cG (length=273) Species: 9606 (Homo sapiens) [Search protein sequence]
VKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQD
CPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELF
SRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSK
RPNAILKLTDFGFAKETTSYVAPEVLYDKSCDMWSLGVIMYILLCGYPPF
YSNPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEF
MNHPWIMQSTKVPQTPLHTSRVL
3D structure
PDB3a2c Structural analysis of an MK2-inhibitor complex: insight into the regulation of the secondary structure of the Gly-rich loop by TEI-I01800
ChainG
Resolution2.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D186 K188 E190 N191 D207 S216
Catalytic site (residue number reindexed from 1) D139 K141 E143 N144 D160 S169
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PDY G V78 Q80 C140 L141 D142 E190 N191 L193 D207 V31 Q33 C93 L94 D95 E143 N144 L146 D160 BindingDB: IC50=130nM
BS02 PDY G Y260 P261 Y264 S265 Y197 P198 Y201 S202 BindingDB: IC50=130nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3a2c, PDBe:3a2c, PDBj:3a2c
PDBsum3a2c
PubMed20057052
UniProtP49137|MAPK2_HUMAN MAP kinase-activated protein kinase 2 (Gene Name=MAPKAPK2)

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