Structure of PDB 2x06 Chain G

Receptor sequence
>2x06G (length=344) Species: 2190 (Methanocaldococcus jannaschii) [Search protein sequence]
MILKPENEKKLIIDVLKKFGVPEEDAKITADVFVDADLKGFTSHGIGRFP
QYITALKLGNINPKPDIKIVKESPATAVIDGDLGLGQVVGKKAMELAIKK
AKNVGVGVVATRNANHFGIAGYYSELAMNQDMIGITITNTEPAMAPFGGK
EKILGTNPIAIAFKGNKYKFSLDMATASIARGKILEALRKKIKIPEGCAV
DKDGKPTTDPAKALEGCILPFGGPKGYGLALAIEMLSAIGGAEVGTKVKG
TANPEERCTKGDLFIAINPEFFMGKEEFKRKVDELLDEIKNSEPAEGFEI
LIPGEIEERNKMKRKDGFEIDKNLYNQLKEICNELGLNIEDYIE
3D structure
PDB2x06 Methanoarchaeal Sulfolactate Dehydrogenase: Prototype of a New Family of Nadh-Dependent Enzymes.
ChainG
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H44
Catalytic site (residue number reindexed from 1) H44
Enzyme Commision number 1.1.1.337: L-2-hydroxycarboxylate dehydrogenase (NAD(+)).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD G F41 H44 H116 F117 G118 A120 T140 T156 P158 D173 M174 L301 I306 E307 F41 H44 H116 F117 G118 A120 T140 T156 P158 D173 M174 L301 I306 E307
BS02 NAD G P224 K225 P224 K225
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
GO:0050545 sulfopyruvate decarboxylase activity
GO:0102443 L-2-hydroxycarboxylate dehydrogenase (NAD+) activity
Biological Process
GO:0019295 coenzyme M biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2x06, PDBe:2x06, PDBj:2x06
PDBsum2x06
PubMed15014443
UniProtQ58820|COMC_METJA L-sulfolactate dehydrogenase (Gene Name=comC)

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