Structure of PDB 2vig Chain G

Receptor sequence

>2vigG (length=375) Species: 9606 (Homo sapiens) [Search protein sequence]

LPETHQMLLQTCRDFAEKELFPIAAQVDKEHLFPAAQVKKMGGLGLLAMD
VPEELGGAGLDYLAYAIAMEEISRGCASTGVIMSVNNSLYLGPILKFGSK
EQKQAWVTPFTSGDKIGCFALSEPGNGSDAGAASTTARAEGDSWVLNGTK
AWITNAWEASAAVVFASTDQNKSISAFLVPMPTPGLTLGKKEDKLGIRGS
STANLIFEDCRIPKDSILGEPGMGFKIAMQTLDMGRIGIASQALGIAQTA
LDCAVNYAENRMAFGAPLTKLQVIQFKLADMALALESARLLTWRAAMLKD
NKKPFIKEAAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERHYRDAR
ITEIYEGTSEIQRLVIAGHLLRSYR

3D structure

PDB

2vig Crystal Structure of Human Short-Chain Acyl Coa Dehydrogenase

Chain

Resolution

1.9 Å

3D
structure

Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Catalytic site (original residue number in PDB)	L154 S155 G271 E392 G404
Catalytic site (residue number reindexed from 1)	L121 S122 G235 E356 G368
Enzyme Commision number	1.3.8.1: short-chain acyl-CoA dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	FAD	G	F152 L154 S155 G160 S161 W185 I186 T187 I387 Y391 T394 E396 L400	F119 L121 S122 G127 S128 W152 I153 T154 I351 Y355 T358 E360 L364
BS02	COS	G	S161 A163 N207 F261 M265 Q266 L268 D269 R272 I342 Y391 E392 G393	S128 A130 N171 F225 M229 Q230 L232 D233 R236 I306 Y355 E356 G357
BS03	FAD	G	R297 F300 L307 Q365 I366 G369	R261 F264 L271 Q329 I330 G333

Gene Ontology

	Molecular Function
GO:0003995	acyl-CoA dehydrogenase activity
GO:0005515	protein binding
GO:0016491	oxidoreductase activity
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors
GO:0016937	short-chain fatty acyl-CoA dehydrogenase activity
GO:0050660	flavin adenine dinucleotide binding

	Biological Process
GO:0006631	fatty acid metabolic process
GO:0006635	fatty acid beta-oxidation
GO:0033539	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GO:0046359	butyrate catabolic process

	Cellular Component
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix
GO:0005813	centrosome

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:2vig, PDBe:2vig, PDBj:2vig
PDBsum	2vig
PubMed
UniProt	P16219\|ACADS_HUMAN Short-chain specific acyl-CoA dehydrogenase, mitochondrial (Gene Name=ACADS)

[Back to BioLiP]