Structure of PDB 2ome Chain G

Receptor sequence
>2omeG (length=330) Species: 9606 (Homo sapiens) [Search protein sequence]
RPLVALLDGRDCTVEMPILKDLATVAFCDAQSTQEIHEKVLNEAVGAMMY
HTITLTREDLEKFKALRVIVRIGSGYDNVDIKAAGELGIAVCNIPSAAVE
ETADSTICHILNLYRRNTWLYQALREGTRVQSVEQIREVASGAARIRGET
LGLIGFGRTGQAVAVRAKAFGFSVIFYDPYLQDGIERSLGVQRVYTLQDL
LYQSDCVSLHCNLNEHNHHLINDFTIKQMRQGAFLVNAARGGLVDEKALA
QALKEGRIRGAALDVHESEPFSFAQGPLKDAPNLICTPHTAWYSEQASLE
MREAAATEIRRAITGRIPESLRNCVNKEFF
3D structure
PDB2ome Crystal structure of human CTBP2 dehydrogenase complexed with NAD(H)
ChainG
Resolution2.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) A130 R272 D296 E301 H321
Catalytic site (residue number reindexed from 1) A98 R240 D264 E269 H289
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD G S106 T134 G189 R190 T191 D210 P211 Y212 C243 N244 N246 N249 A270 A271 R272 A323 W324 S74 T102 G157 R158 T159 D178 P179 Y180 C211 N212 N214 N217 A238 A239 R240 A291 W292
Gene Ontology
Molecular Function
GO:0003714 transcription corepressor activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0051287 NAD binding

View graph for
Molecular Function
External links
PDB RCSB:2ome, PDBe:2ome, PDBj:2ome
PDBsum2ome
PubMed
UniProtP56545|CTBP2_HUMAN C-terminal-binding protein 2 (Gene Name=CTBP2)

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