Structure of PDB 2jbp Chain G

Receptor sequence
>2jbpG (length=287) Species: 9606 (Homo sapiens) [Search protein sequence]
QFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKM
LQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGG
ELFSRIQDRAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSK
RPNAILKLTDFGFAKETTSPYYVAPEVLGPEKYDKSCDMWSLGVIMYILL
CGYPPFYSNSPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQ
RMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERW
3D structure
PDB2jbp Structural basis for a high affinity inhibitor bound to protein kinase MK2.
ChainG
Resolution3.31 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D186 K188 E190 N191 D207 S216
Catalytic site (residue number reindexed from 1) D139 K141 E143 N144 D160 S169
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 P4O G L70 L72 A91 K93 C140 L141 D142 D207 L26 L28 A47 K49 C96 L97 D98 D160 BindingDB: IC50=8.5nM,EC50=49nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2jbp, PDBe:2jbp, PDBj:2jbp
PDBsum2jbp
PubMed17449059
UniProtP49137|MAPK2_HUMAN MAP kinase-activated protein kinase 2 (Gene Name=MAPKAPK2)

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