Structure of PDB 2h0r Chain G

Receptor sequence
>2h0rG (length=216) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
MKTLIVVDMQNDFISPLGSLTVPKGEELINPISDLMQDADRDWHRIVVTR
DWHPSRHISFAKNHKDKEPYSTYTYHSPRPGDDSTQEGILWPVHCVKNTW
GSQLVDQIMDQVVTKHIKIVDKGFLTDREYYSAFHDIWNFHKTDMNKYLE
KHHTDEVYIVGVALEYCVKATAISAAELGYKTTVLLDYTRPISDDPEVIN
KVKEELKAHNINVVDK
3D structure
PDB2h0r Crystal structure of the yeast nicotinamidase Pnc1p.
ChainG
Resolution2.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D8 D51 H53 S59 H94 K122 E129 A163 C167
Catalytic site (residue number reindexed from 1) D8 D51 H53 S59 H94 K122 E129 A163 C167
Enzyme Commision number 3.5.1.19: nicotinamidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN G D51 H53 H94 D51 H53 H94
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
GO:0008936 nicotinamidase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0000183 rDNA heterochromatin formation
GO:0019358 nicotinate nucleotide salvage
GO:0019363 pyridine nucleotide biosynthetic process
GO:0031509 subtelomeric heterochromatin formation
GO:1904524 negative regulation of DNA amplification
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005777 peroxisome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2h0r, PDBe:2h0r, PDBj:2h0r
PDBsum2h0r
PubMed17382284
UniProtP53184|PNC1_YEAST Nicotinamidase (Gene Name=PNC1)

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