Structure of PDB 2fhh Chain G

Receptor sequence
>2fhhG (length=222) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
TTIVALKYPGGVVMAGDRRSTQGNMISGRDVRKVYITDDYTATGIAGTAA
VAVEFARLYAVELEHYEKLEGVPLTFAGKINRLAIMVRGNLAAAMQGLLA
LPLLAGYDIHASDPQSAGRIVSFDAAGGWNIEEEGYQAVGSGSLFAKSSM
KKLYSQVTDGDSGLRVAVEALYDAADDDSATGGPDLVRGIFPTAVIIDAD
GAVDVPESRIAELARAIIESRS
3D structure
PDB2fhh Structure of the Mycobacterium tuberculosis proteasome and mechanism of inhibition by a peptidyl boronate.
ChainG
Resolution2.99 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.25.1: proteasome endopeptidase complex.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 M1N G T301 T321 Q322 S327 A346 G347 T348 A349 T1 T21 Q22 S27 A46 G47 T48 A49
Gene Ontology
Molecular Function
GO:0004298 threonine-type endopeptidase activity
Biological Process
GO:0010498 proteasomal protein catabolic process
GO:0051603 proteolysis involved in protein catabolic process
Cellular Component
GO:0005839 proteasome core complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2fhh, PDBe:2fhh, PDBj:2fhh
PDBsum2fhh
PubMed16468986
UniProtP9WHT9|PSB_MYCTU Proteasome subunit beta (Gene Name=prcB)

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