Structure of PDB 2clp Chain G

Receptor sequence

>2clpG (length=323) Species: 9606 (Homo sapiens)

RPATVLGAMEMGRRMDAPTSAAVTRAFLERGHTEIDTAFVYSEGQSETIL
GGLGLRLGGSDCRVKIDTKAIPLFGNSLKPDSLRFQLETSLKRLQCPRVD
LFYLHMPDHSTPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCK
SNGWILPTVYQGMYNAITRQVETELFPCLRHFGLRFYAFNPLAGGLLTGK
YKYEDKDGKQPVGRFFGNTWAEMYRNRYWKEHHFEGIALVEKALQAAYGA
SAPSMTSATLRWMYHHSQLQGAHGDAVILGMSSLEQLEQNLAAAEEGPLE
PAVVDAFNQAWHLVAHECPNYFR

3D structure

• PDB: 2clp Crystal Structure of Human Aflatoxin B1 Aldehyde Reductase Member 3
• Chain: G
• Resolution: 3.0 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): D73 Y78 P109 H142
• Catalytic site (residue number reindexed from 1): D36 Y41 P72 H105
• Enzyme Commision number: 1.-.-.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NDP	G	G44 M46 D73 Y78 H142 S172 N173 Q198 F226 N227 P228 L229 A230 G231 G232 T235 K237 R251 I315 G317 M318 S319 Q323 Q326 N327	G7 M9 D36 Y41 H105 S135 N136 Q161 F189 N190 P191 L192 A193 G194 G195 T198 K200 R214 I278 G280 M281 S282 Q286 Q289 N290
BS02	CA	G	H269 E272	H232 E235

Gene Ontology

Molecular Function

• GO:0004033 aldo-keto reductase (NADPH) activity
• GO:0005515 protein binding
• GO:0009055 electron transfer activity
• GO:0016491 oxidoreductase activity
• GO:0042802 identical protein binding

Biological Process

• GO:0006081 cellular aldehyde metabolic process

Cellular Component

• GO:0005737 cytoplasm
• GO:0005794 Golgi apparatus
• GO:0005829 cytosol
• GO:0070062 extracellular exosome

External links

• PDB: RCSB:2clp, PDBe:2clp, PDBj:2clp
• PDBsum: 2clp
• UniProt: O95154|ARK73_HUMAN Aflatoxin B1 aldehyde reductase member 3 (Gene Name=AKR7A3)