Structure of PDB 1w0c Chain G

Receptor sequence
>1w0cG (length=263) Species: 5664 (Leishmania major) [Search protein sequence]
VPVALVTGAAKRLGRSIAEGLHAEGYAVCLHYHRSAAEANALSATLNARR
PNSAITVQADLSNVATAPAPVTLFTRCAELVAACYTHWGRCDVLVNNASS
FYPTPLLRNDREAMETATADLFGSNAIAPYFLIKAFAHRVAGTPAKHRGT
NYSIINMVDAMTNQPLLGYTIYTMAKGALEGLTRSAALELAPLQIRVNGV
GPGLSVLVDDMPPEGHRSKVPLYQRDSSAAEVSDVVIFLCSSKAKYITGT
CVKVDGGYSLTRA
3D structure
PDB1w0c Inhibition of Leishmania Major Pteridine Reductase by 2,4,6-Triaminoquinazoline: Structure of the Nadph Ternary Complex
ChainG
Resolution2.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R17 D181 Y194
Catalytic site (residue number reindexed from 1) R12 D159 Y172
Enzyme Commision number 1.5.1.33: pteridine reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP G R17 L18 H38 R39 S40 L66 N109 A110 S111 S112 D142 M179 D181 K198 P224 L226 S227 R12 L13 H33 R34 S35 L61 N97 A98 S99 S100 D120 M157 D159 K176 P202 L204 S205
BS02 TAQ G R17 S111 F113 Y194 L229 R12 S99 F101 Y172 L207 BindingDB: Kd=58750nM
Gene Ontology
Molecular Function
GO:0004155 6,7-dihydropteridine reductase activity
GO:0016491 oxidoreductase activity
GO:0047040 pteridine reductase activity
Biological Process
GO:0006729 tetrahydrobiopterin biosynthetic process
GO:0031427 response to methotrexate
Cellular Component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:1w0c, PDBe:1w0c, PDBj:1w0c
PDBsum1w0c
PubMed15388924
UniProtQ01782|PTR1_LEIMA Pteridine reductase 1 (Gene Name=PTR1)

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