Structure of PDB 6sga Chain FJ

Receptor sequence

>6sgaFJ (length=353) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence]

VNKQTQKYRTKLRYRFRQPSVVPLRQTLQQRHNTILEVLRRRRINSGDQS
PYRYVEERLYSKPSRLDREGVKVNKTYALQGLGDLEPLRYGANFGISEKD
ALKYETVAEKAKYMEPPIPYSSLAARKLAAGALWPAAPDPEGMISKEVRL
LRHESSMSPSARAFSERVAYHLRRSLKACPGHIAEHIDFTQLIIQEVLGS
RRSKEIYIVWFTVDPGARFELEPRLHQLNHWVQQLIIKRVKRRPHIPRVT
WIYDGGRLERELPRDVKQELQSFVADAATTLESRVKYLKELDTMNQRMKD
IPWFMPYLWSKEEKAARQKSMLADLEEVERRKNEHSSGRSAPPRTSPPPQ
FVR

3D structure

PDB

6sga Mitoribosomal small subunit biogenesis in trypanosomes involves an extensive assembly machinery.

Chain

Resolution

3.1 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	FJ	R293 L297 W318 E322	R284 L288 W309 E313
BS02	rna	FJ	V10 N11 K12 Q13 T14 Q15 Y17 T19 K20 L21 R22 Y23 R24 F25 R26 Q27 V30 V31 L33 R34 Q58 S59 R62 T115 E150 V157 R161 S167 S169 S209 R210 R211 K213 E214 Y216 H239 Q242 I246 R248 K250 R251 R252 I255 R257 K320	V1 N2 K3 Q4 T5 Q6 Y8 T10 K11 L12 R13 Y14 R15 F16 R17 Q18 V21 V22 L24 R25 Q49 S50 R53 T106 E141 V148 R152 S158 S160 S200 R201 R202 K204 E205 Y207 H230 Q233 I237 R239 K241 R242 R243 I246 R248 K311

External links

PDB	RCSB:6sga, PDBe:6sga, PDBj:6sga
PDBsum	6sga
PubMed	31515389

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